Outcomes of Diabetes In Hospitalized COVID-19 Patients At Assiut University Hospital
试验速览
- 阶段
- 不适用
- 入组人数
- 160
- 主要终点
- Mortality rates
研究概览
简要总结
Coronavirus disease (COVID-19), a global pandemic affecting the whole world and taking the lives of millions. The majority of fatalities occur in the elderly specially in the presence of chronic diseases such as diabetes mellitus (DM), hypertension, obesity, cardiovascular disease, chronic kidney disease and cancer.
详细描述
Knowing about the family of coronaviruses is that they are the cause of a variety of well-known diseases affecting humans, ranging from common cold to the Middle East Respiratory Syndrome (MERS) and Acute Severe Respiratory Syndrome (SARS), and now the COVID-19 as a new problematic family member.
Regarding DM as a knowing old health problem, it has been found that we can use it in predicting the prognosis of the COVID-19 as admission to intensive care unit, invasive ventilation or even death.
Previous studies confirmed that uncontrolled DM can badly affects innate immunity which considered as the first line of defence mechanism against COVID-19 infection.
In addition, DM has a pro-inflammatory effect through exaggeration of cytokine response which appears clearly through higher results of serum levels of interleukin-6 (IL-6), C-reactive protein and ferritin, this suggests that people with DM are more venerable to cytokine storm which leads to Acute Respiratory Distress Syndrome (ARDS), shock and rapid deterioration of the case.
On the other hand, on looking to previous studies and data collected about the prior SARS outbreak in 2003, which suggested that COVID-19 can lead to worsening of glycemic control in known diabetic patients and above that caused by the stressful nature of a critical illness.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cases aged 18 years and over.
- •Cases diagnosed as COVID-19 positive.
- •Cases admitted to Assiut University Hospitals.
排除标准
- •Age less than 18 years.
- •Outpatient management (even in confirmed cases of COVID-19).
结局指标
主要结局
Mortality rates
时间窗: up to 1 year
mortality rate among diabetic and non diabetic COVID-19 patients
Need for ICU admission
时间窗: up to 1 year
who will need ICU admission during patient hospitalization
Hospital stays
时间窗: up to 1 year
for how long patients admitted to hospital
Need for ventilatory support
时间窗: up to 1 year
who will need for ventilatory support (Non-Invasive ventilation (NIV), High Flow Nasal Cannula (HFNC) and Invasive Mechanical Ventilation (IMV).
次要结局
- Exacerbation of chronic complications of diabetes(up to 1 year)
- Incidence of other complications(up to 1 year)
- Glycemic control(up to 1 year)
- Newly onset DM will appear among non-diabetic patients(up to 1 year)
- Acute complications of diabetes(up to 1 year)
- Changes of diabetes management plan(up to 1 year)
研究者
Martina Saad Lamey
Principal Investigator
Assiut University