ISRCTN51287266已完成未知
Incidence and pathogenesis of invasive aspergillosis in intensive care patients with severe influenza or COVID-19 (AspiFlu)
St George’s University Hospitals NHS Foundation Trust0 个研究点目标入组 357 人开始时间: 2019年12月6日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 357
研究概览
简要总结
2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37657925/ (added 13/02/2024)
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
入选标准
- •Current inclusion criteria as of 13/01/2022:
- •1. Adults > 18 years
- •2. Admitted to ICU for respiratory support requiring intubation and ventilation for >24h
- •AND EITHER:
- •3. Positive influenza or SARS-CoV-2 PCR from nasal, throat swab, BAL or other respiratory specimen taken either < 7 days pre, or < 3 days post, admission to ICU
- •4. Influenza or SARS-CoV-2 suspected but PCR results awaited – under these circumstances the patient can be provisionally enrolled, but later excluded if no specimens taken within either < 7 days pre, or < 3 days post admission to ICU positive as above
- •5. Clinically suspected bacterial lower respiratory tract infection with associated radiological changes (pneumonia) encompassing both community and hospital-acquired pneumonia diagnosed =72hrs prior to ICU admission or =48 hours after admission. These patients must not have tested positive for influenza or SARS-CoV-2 PCR during their hospital admission
- •Previous inclusion criteria as of 26/03/2020 - 13/01/2022:
- •1. Adults aged >18 years
- •2. Admitted to ICU for respiratory support requiring intubation and ventilation for >24 hours
- •AND EITHER:
- •3. Positive influenza or SARS-CoV-2 PCR from nasal, throat swab, BAL or other respiratory specimen taken either < 7 days pre, or < 3 days post, admission to ICU
- •4. Influenza or SARS-CoV-2 suspected but PCR results awaited – under these circumstances the patient can be provisionally enrolled, but later excluded if no specimens taken within either < 7 days pre, or < 3 days post admission to ICU positive as above
- •Previous inclusion criteria:
- •1. Adults > 18 years
- •2. Admitted to intensive care for respiratory support requiring intubation and ventilation for > 24 hours
- •AND EITHER:
- •3. Positive influenza PCR from nasal, throat swab, BAL or other respiratory specimen taken within 48 hours (of admission to ICU – pre or post
- •4. Influenza suspected but influenza PCR results awaited – under these circumstances the patient can be provisionally enrolled, but later excluded if no specimens taken within 48 hours pre/post admission to ICU is positive as above
排除标准
- •1. Respiratory failure not the primary reason for ICU admission
- •2. History of proven/ probable invasive pulmonary aspergillosis
研究者
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