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临床试验/NCT07285720
NCT07285720招募中不适用

Phonological Constraints on Language Development in Individuals With Williams Syndrome

Centre Hospitalier Universitaire, Amiens2 个研究点 分布在 1 个国家目标入组 130 人开始时间: 2024年7月5日最近更新:

试验速览

阶段
不适用
状态
招募中
入组人数
130
试验地点
2
主要终点
questionnaire score of patients with WS caracterisation

研究概览

简要总结

Williams syndrome (WS) is a neurodevelopmental disease characterized by mild to moderate intellectual disability and an extremely heterogeneous cognitive profile. Research has outlined two main features of WS: an atypical social behavior associated with surprising language abilities, and a hyperacusis. The purpose of this project is to investigate the relationships between both these abilities, and particularly the role of the hyperacusis on language abilities. The hyperacusis would be crucial in developing language skills: the apparent strength in the verbal domain could rely on Phonological Short Term Memory (PSTM) more in individuals with WS than in typically developing individuals. In addition, the investigators will compare individuals with WS to individuals with Down syndrome (DS): DS is often associated to strong limitations in the PSTM with poor language abilities. To this end, the investigators will use a highly innovative approach including physiological assessments (EEG-NIRS protocol) and questionnaires. The performance of people with WS will be compared to those of participants with DS and TD participants of same DA and cognitive assessments.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Parallel
主要目的
Basic Science
盲法
None

入排标准

年龄范围
6 Years 至 —(Child, Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • For SW and SD: genetic diagnosis and aged between 6- and 17 years old.
  • For typical participants: any child, adolescent or young adult of the same developmental or chronological age (between 6 and 17 years of age)
  • adult group (between 20 and 60 years).

排除标准

  • Autistic Associated Disorders,
  • West syndrome

结局指标

主要结局

questionnaire score of patients with WS caracterisation

时间窗: 2 years

questionnaire score for cognitive profile of patients with WS caracterisation

次要结局

  • Impact of hyperacusis on questionnaire score(2 years)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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