NCT00298376Unknown不适用
Oral Tolerance in Cow's Milk Allergy in the Infant: Role of CD4+CD25+ T Cells and Intestinal Microflora
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
研究概览
简要总结
This study aims to determine if there is a link between cow's milk allergy in infants and regulatory T cells dysfunction that should be transient in infant acquiring oral tolerance after 12 month avoiding food and persistent in others.
Cow's milk allergy is evaluated by basophils activation test, T cells activation test, specific humoral response (IgA, IgE, IgG) in allergic infants before and after 12 month avoiding food, before and after low dose milk exposure, before and after oral challenge.
Number and function of regulatory T cells and microflora composition are measured at the same time.
Allergic infants are compared to age matched control group.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Month 至 15 Months（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •male or female, age before 6 month, cow's milk allergy with positive prick or patch test for cow's milk
- •Control group: male or female, age before 6 month or within 12 and 18 month, eating cow's milk every day
排除标准
- •immunodeficiency syndrome, lactose intolerance Control group: other food allergy, atopic dermatitis.
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Specific Oral Tolerance Induction in Children Allergic to Cow's Milk ProteinsCow's Milk Protein SensitivityNCT01641731Instituto de Investigación Hospital Universitario La Paz55
进行中（未招募）
不适用
Evaluation of Tolerance, Efficacy and Safety of an Hydrolyzed Formula in Infants With IgE/Non-IgE Mediated CMA.Cow's Milk AllergyNCT06481280United Pharmaceuticals70
已完成
2 期
Study of Milk Allergy and Tolerance in ChildrenFood HypersensitivityMilk HypersensitivityNCT00778258National Institute of Allergy and Infectious Diseases (NIAID)170
已完成
不适用
Early Oral Immunotherapy in Infants With Cow's Milk Protein AllergyHypersensitivity, MilkNCT03586388IRCCS Burlo Garofolo73
Unknown
不适用
Cow's Milk Allergy in Infants With Obstructive Sleep Apnea (OSA)Obstructive Sleep Apnea SyndromeNCT00659854Soroka University Medical Center50