Appetite-regulating Hormones, the Gut Microbiome and the Metabolome in Children With Failure to Thrive
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Appetite-regulating hormones (ghrelin, PYY, leptin) measured by fasting blood samples
研究概览
简要总结
Failure to thrive (FTT) is an expression for inadequate growth in the early childhood and thus, a sign of undernutrition. This study will include children with FTT, and compare with existing data from children with normal and excessive growth.
The overall aim of this study is to explore whether 1) children who develop FTT with no organic explanation differ from healthy normal weight and overweight children in their basal level of appetite-regulating hormones and 2) if inadequate, normal and excessive growth in children can be partly predicted by variation in their gut microbiome and metabolome.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 12 Months 至 36 Months（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with failure to thrive
- •Weight for height > 1.9 SD below the median by use of the WHO Child Growth Standards
- •Age between 12-36 months
排除标准
- •Inflammatory bowel disease
- •Celiac disease
- •Immunodeficiency
- •Other somatic disease that can explain the growth failure
结局指标
主要结局
Appetite-regulating hormones (ghrelin, PYY, leptin) measured by fasting blood samples
时间窗: At subject enrollment
次要结局
- Metabolome measured by urine samples(At subject enrollment)
- Head circumference measured in centimeters(At subject enrollment)
- Microbiota composition measured by fecal samples(At subject enrollment)
- Body weight measured in kilograms(At subject enrollment)
- Waist circumference measured in centimeters(At subject enrollment)
- Metabolic markers (insulin, glucose) measured by fasting blood samples(At subject enrollment)
- Height measured in centimeters(At subject enrollment)
研究者
Lena Kirchner Brahe
Assistant professor, PhD
University of Copenhagen