Detection of Microplastics in Cardiac Surgery Patients: Its Metabolic Pathways and Toxic Effects
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 主要终点
- Detection of microplastics in human heart tissue and the blood
研究概览
简要总结
The exponential growth in plastic production/use translates into a parallel increase in environmental plastic waste, which is constantly degraded into microplastics and nanoplastics. Information on the effects of microplastics on human health is still preliminary.
Cardiac surgery patients is a population high exposed to plastics. This observational study will obtain biological samples of cardiac surgery patients as a reference and vulnerable group of individuals highly exposed to microplastics and potentially more susceptible.
The objective of this research is to be able to detect microplastics on blood and operation samples of cardiac surgery patients as well as their potential genotoxic and immunological damage.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years
- •Elective cardiac surgery
排除标准
- •Emergency surgery or limited-term surgery
- •Previous cardiac surgery
- •Previous severe liver disease
- •Pregnant or planning to become pregnant
- •Have a malignant tumor
结局指标
主要结局
Detection of microplastics in human heart tissue and the blood
时间窗: perioperative: preoperative and pro-/postoperative blood and intraoperative heart tissue
Detection of microplastics in human heart tissue and the blood undergoing cardiac surgery
次要结局
未报告次要终点
研究者
Kun Hua
Deputy Chief Surgeon
Beijing Anzhen Hospital