General Risk Factors and Inflammatory Determinants in Older Patients With Asthma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Differences in number and activation status of inflammatory cells in sputum and blood
研究概览
简要总结
A cross-sectional study in asthma patients to determine if a late age of onset asthma (start symptoms >18 years old), is associated with more persistent airway/systemic inflammation, worse asthma control, more co-morbidity, a different microbiome and poorer quality of life despite the use of optimized asthma therapy.
详细描述
For ages, asthma has been considered a disease for children and young adults. However, nowadays 30% of all asthma patients is over 50 years old. Asthma in the elderly is generally more severe and approximately 50% of all deaths drom asthma occur in this age group. With rapid aging of the global population, the burden of asthma in the elderly will further increase.
Asthma is a heterogeneous disease and the question is whether asthma in the elderly can be considered the same disease as asthma in children and young adults. The pathophysiology and risk factors of asthma in the elderly are still not completely understood. Good characterization of asthma in the elderly requires clinical phenotyping as well as a thorough analysis of the underlying cellular and molecular mechanisms. It is hypothesized that in older asthma patients, a late age of onset (start asthma symptoms >18 years) is associated with more persistent airway/systemic inflammation, worse asthma control, more co-morbidity and poorer quality of life despite the use of optimized asthma therapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Smoking history of > 10 PY
- •Age < 18 years or > 80 years
- •Not able to speak or write Dutch language.
- •Not able to perform lung function test/sputum induction
- •ACQ < 0,75
- •Other diseases which could influence pulmonary function and/or the immune system such as: o A possible infection of the upper- or lower respiratory tract 4 weeks prior to the collection of materials;
- •Chronic obstructive pulmonary disorder (COPD) in the medical history;
- •Auto-immune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), myasthenia gravis or Goodpasture's syndrome;
- •Malignancies;
- •Inherited or acquired immunodeficiency
- •Pregnancy;
- •Exclusion criteria healthy controls:
- •Asthma, as defined earlier (page 13);
- •An abnormal spirometry with a forced vital capacity (FVC) or FEV1 below the 80% of the predicted value
- •A liaison with the coordinating or principal investigator, which could likely influence the decision to participate in this study voluntarily (in concordance with the World Meteorological Organization (WMO) -article 5);
结局指标
主要结局
Differences in number and activation status of inflammatory cells in sputum and blood
时间窗: 1 month
To compare the differences in number and activation status of inflammatory cells in sputum and blood of different subgroups of asthmatics.)
次要结局
- Inflammatory profile(1 month)
- Detection of different microbiome subgroups of asthmatics and compare with controls.(1 month)
- Hair cortisol(1 month)
- The effect of aging on inflammation, physiology, psychology and co-morbidities in asthma.(1 month)
- Interleukin cell type 2 (ILC2) correlation and disease phenotype(1 month)
- Selfmanagement / coping strategies(1 month)
研究者
Gerdien Tramper
MD PhD
Franciscus Gasthuis