Dexmedetomidine Versus Fentanyl on Time to Extubation in Patients With Morbid Obesity Undergoing Laparoscopic Sleeve Gastrectomy: A Randamized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- The time for extubation
研究概览
简要总结
This study aims to compare the efficacy of dexmedetomidine versus fentanyl during general anesthesia for patients with morbid obesity undergoing laparoscopic sleeve gastrectomy.
详细描述
The use of opioids in surgeries for patients with morbid obesity is controversial since they are known for having ventilatory depressing effects. Therefore, alternative analgesics are needed to improve anesthetic management for patients with obesity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age from 20 to 50 years old.
- •Both sexes.
- •American Standards Association (ASA) physical status II - III.
- •Body Mass Index (BMI) ≥ 35 kg/m2.
排除标准
- •Allergy to α2 -adrenergic agonist.
- •History of cardiac disease (uncontrolled hypertensive patient with blood pressure above 140/90, implanted pacemaker, poor cardiac function (ejection fraction< 50%), history of myocardial infarction, cerebral stroke, transient ischemic attack, or coronary artery disease with or without stents.
- •Neuromuscular disease, liver disease (coagulopathy INR>1.5 or platelet count <100.000/μl), renal impairment (serum creatinine >1.2mg/dl, serum K >5.5mmol/l).
- •Opioid medication within 24 hours before the operation.
- •Respiratory diseases as COPD, uncontrolled asthmatic patients.
研究组 & 干预措施
Group F (fentanyl group)
Fentanyl (1 μg/kg) was given intravenously slowly over 60 seconds before induction of anesthesia as a loading dose followed by continuous infusion at a rate of (1μg/kg/hr) after intubation. It was stopped 10 minutes before the end of surgery.
干预措施: Group F (fentanyl group) (Drug)
Group D (dexmedetomidine group)
The patients were received a loading dose of dexmedetomidine (1 μg/kg) intravenously over 15 minutes before induction of anesthesia, followed by continuous infusion at a rate of (0.6 μg/ kg/ hr) after intubation and was stopped 10 minutes before the end of surgery.
干预措施: Group D (dexmedetomidine group) (Drug)
结局指标
主要结局
The time for extubation
时间窗: 30 minutes till end of surgery.
Time from end of anesthesia till safe extubation of the patients
次要结局
- Mean arterial blood pressure (MAP)(Intraoperatively.)
- Heart rate (HR)(Intraoperatively)
- Incidence of hypotension(Intraoperatively)
研究者
Doha Mohammed Bakr
Assistant lecturer in Anesthesiology, Intensive care and Pain management, Faculty of Medicine, Helwan University, Qism Helwan Egypt.
Helwan University