The behaviour of and change to corneal dendritic cell dynamics before and after anti-inflammatory and immunosuppressant eye drops are topically applied into the eye of healthy individuals.

Queensland University of Technology0 个研究点目标入组 90 人开始时间: 2021年5月4日最近更新: 2022年11月14日

试验速览

暂无简介。

•Participants must satisfy the following conditions prior to inclusion in the study:
•A)Aged at least 18 years
•B)Good ocular health
•C)Willing and able to comply with protocol (e.g. attend study visit)
•D)Existing wearers should discontinue lens wear for at least 24 hours prior to examination.
•E)Participants without dry eye will be included.
•F)Former contact lens wearers will be included

•Any of the following will render a participant ineligible for inclusion:
•A)Current pregnancy, breastfeeding or traying to become pregnant
•B)History of ocular trauma or surgery such as LASIK or PRK
•C)Current or long-term use of topical ocular medication
•D)Ocular disease or systemic disease that may affect the cornea or conjunctiva (epithelial defects, ulcers and corneal epithelial or basement membrane dystrophies).
•E)Use of orthokeratology contact lenses within the past 3 months
•G)Use of soft contact lenses in either eye within 1 month of the study or rigid gas permeable contact lenses within 3 months of the study
•H)Dry eye disease (defined as defined as a 5-Item dry eye questionnaire (DEQ-5) score equal to 7.
•AND failing at least one of the objective dry eye tests Non-Invasive Break-Up Time with less than or equal to 10s, or Corneal Fluorescein Staining with greater than or equal to 5 corneal spots.
•(Note: both eyes will be assessed, and the worst eye will contribute toward the dry eye diagnosis)
•H) Allergy to fluorometholone, lifitegrast or any of the excipients of the study drugs

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