Strength Training Response of Muscle in GLP-1 Users
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Balance testing - Percentage of failed recoveries
研究概览
简要总结
GLP-1 medication is being prescribed for weight loss. However, GLP-1 medication may adversely affect muscle mass and muscle function. Moreover, any loss of muscle mass or muscle function with GLP-1 treatment may impair balance and increase fall risk. This is a particular concern among older adults already susceptible to the common muscle strength and muscle function loss with age, yet there is little evidence among this population. This study will address a gap in knowledge regarding the effects of GLP-1 treatment on muscle mass, muscle function, and balance/fall risk among adults age 50 and older.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age, 50y+
- •Be taking GLP-1 medicine (Weygovy or Zepbound) for 1 month or less
- •Weight <300 lb
- •Pass a health and exercise readiness screening
排除标准
- •Weight >300 lb
- •Osteoporosis
- •Active metabolic, neoplastic, or cardiovascular disease
- •Unable or unwilling to provide consent
研究组 & 干预措施
Strenth Training
Participants will undergo strength training 3 times per week for 14 weeks.
干预措施: Strength Training (Behavioral)
Waitlisted control
Participants will have no strength training intervention for 14 weeks. Participants will be offered the same 14-week strength training program after the initial 14 weeks.
干预措施: Wait first, then strength training (Other)
结局指标
主要结局
Balance testing - Percentage of failed recoveries
时间窗: 2-hour testing session in lab at baseline and 14 weeks.
Participants will stand on the treadmill with the belt stationary. The belt will then suddenly change to a speed specified by the investigator, and the participant will attempt to step to maintain their balance and establish a stable gait. In addition to the treadmill itself, this system includes an integrated fall arrest harness that is anchored to an overhead gantry that is fixed to the treadmill. This harness prevents any body part but the feet from impacting the treadmill in the event that the participant is unable to maintain their balance after a sudden change in speed.
Muscle mass by d3-creatine dilution
时间窗: Water containing creatine isotope consumed in lab; Urine sample collection on Day 0 and Day 3 at baseline and 14 weeks.
Participants will collect a urine sample prior to be provided a creatine capsule containing 30 milligrams of a naturally-occurring creatine isotope. A glass of water will be provided to wash it down. Participants will be asked to return \~3 days later to provide another urine sample. Urine samples will be analyzed at an off-site laboratory to determine changes in d3-creatine excretion before and after the 14-week strength training intervention.
次要结局
- Muscle function(500-meter timed walk in lab at baseline and 14 weeks)
研究者
Kevin Davy
Professor
Virginia Polytechnic Institute and State University