Infections in Stable Asthmatic Patients: Non Invasive Detection - Infections in Stable Asthmatic Patients: Non Invasive Detection

Academisch Medisch Centrum0 个研究点目标入组 45 人开始时间: 待定最近更新: 2024年5月13日

适应症

试验速览

暂无简介。

•- Men and/or women age between 18-65 years
•- History of episodic chest tightness and wheezing (for the MILD and SEVERE astmatic patients)
•- Prebronchodilator FEV 1 *80% predicted (for the MILD asthmatic patients)
•- Reversibility in FEV1>12% predicted, or documented hyperesponsiveness (PC20 methacoline < 4mg/ml) during the past 12 months.
•- Steroid-naïve (for the MILD asthmatic patients)
•- Non smoking or ex-smokers (stopped more than 12 months ago and 5 pack year or less).
•- Proven skin prick test. (for the MILD asthmatic patients)
•- Use of high doses of inhaled corticosteroids (* 1000 µg/day beclomethasone or equivalent) and long acting bronchodilators for more than 12 months. (for the SEVERE athmatic patients)
•- One severe asthma exacerbation requiring oral steroid therapy during the past 12 months. (for the SEVERE athmatic patients)
•- Baseline FEV1*75% of predicted or negative documented airway hyperresponsiveness (PC20 methacoline>8mg/ml) (for the HEALTHY subjects)
•- Negative history of pulmonary and any other relevant diseases. (for the HEALTHY subjects)

•- History of current alcohol or drug abuse, as judged by the investigator.
•- Subjects who have had an exacerbation or a chest infection within the last 4 weeks prior to the study.
•- Uncontrolled hypertension-systolic blood pressure(BP)>200 mmHg and/or diastolic BP>100 mmHg.
•- Concomitant disease or condition which could interfere with the conduct of the study or which would, in the opinion of the investigator, pose an unacceptable risk to the patient in this study

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