NCT06841471招募中不适用
Association Between Corneal Sensitivity, Nerve Morphology, Tear Film Homeostasis and Dry Eye Symptoms
Daniela Nosch1 个研究点 分布在 1 个国家目标入组 140 人开始时间: 2025年2月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 140
- 试验地点
- 1
- 主要终点
- Differences of corneal nerve function and morphology in relation with DED signs
研究概览
简要总结
This study aims to determine whether corneal nerve function and morphology are affected by tear film instability and ocular surface homeostasis loss. Additionally, it seeks to investigate whether these factors vary based on the severity of dry eye symptoms.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Group with DED: Diagnosis of DED based on the TFOS DEWS II report
- •Group without DED: No diagnosis of DED
排除标准
- •Exclusion criteria:
- •Systemic disease that may affect ocular health and innervation
- •injury or history of operations on the anterior or posterior segment of the eye, which can affect the corneal structure and physiology
- •regular application of systemic or ocular medication known to affect the tear film except from DED medications
- •eye drops or makeup on the day of measurement.
- •Contact lens wearers are asked not to wear contact lenses for 1 week before the first appointment.
- •Participant with DED medications will be asked to use only conservative-free eye drops on the days of examination
结局指标
主要结局
Differences of corneal nerve function and morphology in relation with DED signs
时间窗: within one week
Correlation coefficient between corneal sensitivity and corneal nerve morphology, and variables related to tear film stability and corneal surface homeostasis.
次要结局
- Differences of corneal nerve function and morphology in relation with DED symptoms(within one week)
研究者
Daniela Nosch
Lecturer
University of Applied Sciences and Arts Northwestern Switzerland
研究点 (1)
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