Gene Expression Changes in Young and Geriatric Skin
试验速览
- 阶段
- 早期 1 期
- 状态
- 招募中
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Change in expression genes involved in protecting skin cells from UVB damage in younger skin and geriatric skin injected with IGF-1 from baseline
研究概览
简要总结
This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults. Sunlight exerts many effects on the body. There is evidence that in response to ultraviolet B radiation (UVB), which are the burning rays of sunlight, young adult skin responds differently than geriatric skin. In fact, researchers feel that this difference in how the skin reacts to UVB is why skin cancers are found in older skin. Researchers believe that a major difference between young adult and geriatric skin is that young skin has a lot of a protein called insulin-like growth factor-1 (IGF-1), whereas geriatric skin has very little. The current study will test how young adult versus geriatric skin responds to UVB, and if geriatric skin treated with an injection of small amount of IGF-1 drug will then act like young skin.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male/Female
- •White skin (Fitzpatrick types I and II)
- •Age 21-30 or 65 and older
- •Able to comprehend procedures/risks
排除标准
- •Known photosensitivity
- •Currently on photosensitizing medications
- •Diabetes Mellitus
- •History of abnormal scarring
- •History of skin infections
- •Known allergy to lidocaine local anesthetic
- •Pregnancy or nursing
- •Other serious health issues
研究组 & 干预措施
Geriatric Adult
Four small areas will undergo injection of a small amount of IGF-1 drug and two will undergo injections with saline. Then the injected areas will be treated with a small amount of UVB.
干预措施: Insulin-Like Growth Factor 1 (Drug)
Young Adult
One small area of skin will undergo treatment with a small amount of UVB.
干预措施: No Insulin-Lie Growth Factor 1 (Other)
结局指标
主要结局
Change in expression genes involved in protecting skin cells from UVB damage in younger skin and geriatric skin injected with IGF-1 from baseline
时间窗: 2 Days
Expression genes involved in protecting skin cells from UVB damage, including p21, xeroderma pigmentosum (XPC), and polymerase eta, will be higher following UVB exposure in younger skin and geriatric skin injected with IGF-1 than in geriatric skin injected with saline as a control.
次要结局
未报告次要终点