Placebo-controlled Study on Intervention Effect of Coffee on Glucose and Lipid Homeostasis Disorders
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 156
- 试验地点
- 1
- 主要终点
- Change in blood glucose from baseline
研究概览
简要总结
The purpose of this study is to research the changes of typical thermal processing food intervention on health outcome, metabolites, and gut microbiota, in order to explore the molecular mechanism of interaction between maillard reaction associated hazards and complex food matrix, and provide scientific basis and reference model for combining food nutrition and safety protection.
详细描述
This study investigated the association of potato, fried potato, unfried potato, and sweet potato consumption with the incidence of mortality in the China Health and Nutrition Survey (CHNS).We analyzed the CHNS data and the participants (n = 14,116) over 20 years old were followed for up to 22 years. The participants were initially free of cancer, myocardial infarction, apoplexy, and pregnancy. Potato consumption was assessed using validated semi-quantitative food questionnaires (FFQ) in interviews. In each wave of interviews, the participants' situations such as alive, dead, or dying was listed and the death months were recorded. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazard models with adjustment of potential confounders.In the CHNS cohort, total potato, fried potato, unfried potato, and sweet potato consumption were all strongly associated with a reduction in all-cause mortality in both Chinese women and men.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 17 Years 至 29 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Non-smoking, non-occupational exposed healthy volunteers, 18.5<BMI<30 kg/m^2, were screened. If the evaluation of disease history, blood biochemistry and blood routine was normal, the volunteers were considered healthy.
排除标准
- •The main exclusion criteria included people with high exposure to cold and fever, recent drug intake (including dietary supplement intake), alcohol intake, vegetarians, pregnancy, high-temperature processed meat and beverages such as coffee and milk tea.
结局指标
主要结局
Change in blood glucose from baseline
时间窗: 8 weeks
Change in blood lipids from baseline
时间窗: 8 weeks
次要结局
- Change in gut microbiota(8 weeks)
- Urinary biomarkers levels of acrylamide, furans, and furfuryl alcohol(8 weeks; 24 hours)
- Change of metabolites(8 weeks)
研究者
Yu Zhang
Professor
Zhejiang University