The Effect of Transcranial Direct Current Stimulation on Visual Attention - a Combined MRI and Non-invasive Brain Stimulation Single Session Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Visual-attention task accuracy
研究概览
简要总结
Recently, attention has been drawn to non-invasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS), in order to enhance cognitive functions by modifying brain plasticity and use it in different healthy and diseased populations. In the current research, investigator aim to examine the short-term effects of multiple tDCS protocols in healthy adults population on visual attention and identify the neural underpinnings of tDCS-induced behavioral aftereffects using a combined tDCS/ MRI network-based approach.
详细描述
Investigator will investigate the shor-term effects of active tDCS as compared to a placebo stimulation on visual attention in the healthy seniors. A cross-over, randomized, placebo-controlled design will be used. Single tDCS sessions will be performed in 4 sessions over distinct brain areas with ongoing visual attention training. During the stimulation, investigator will use the visual matching task. MRI protocol consisting of T1 and resting state fMRI sequences will be acquired before and after every stimulation session in order to search for active vs. placebo tDCS-induced changes in brain activation and resting state functional connectivity and to identify neural correlates of behavioral changes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •right handed, healthy volunteers in two groups - healthy adults under 40 years, healthy seniors over 50 years
排除标准
- •psychiatric disorders, including major depression, major vascular lesions, and other brain pathologies detected by MRI that might present with cognitive decline
- •a cardio pacemaker or any MRI-incompatible metal in the body
- •any diagnosed psychiatric disorder
- •alcohol/drug abuse
- •lack of cooperation
- •presence of cognitive impairment
研究组 & 干预措施
Sham transcranial direct current stimulation
Healthy adults and healthy seniors will undergo application of sham transcranial direct current stimulation over two distinct brain areas.
干预措施: Transcranial direct current stimulation (Device)
Real transcranial direct current stimulation
Healthy adults and healthy seniors will undergo application of real transcranial direct current stimulation over two distinct brain areas.
干预措施: Transcranial direct current stimulation (Device)
结局指标
主要结局
Visual-attention task accuracy
时间窗: Change from baseline immediately after completion of stimulation protocol
Task will be presented on a computer and subject will respond by YES-NO buttons. Only if there are no differences in task accuracy, we will measure task reaction times (e.g. due to the roof effect).
Magnetic resonance imaging
时间窗: Change from baseline immediately after completion of stimulation protocol
Investigator will record high resolution structural T1-weighted (MPRAGE) images, functional T2\* weighted multiband EPI sequences. The total time spent in the scanner will be approximately 40 in every session.
次要结局
未报告次要终点