NCT00861900已完成不适用
Immune Mechanisms of Rejection in Human Lung Allografts
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 778
- 主要终点
- The primary efficacy event is the change in pulmonary function testing values (FEV1).
研究概览
简要总结
The investigators have obtained compelling evidence that the development of anti-human leukocyte antigen (anti-HLA) antibodies against mismatched donor antigens significantly correlates with the development of bronchiolitis obliterans (BOS). Further, these anti-HLA antibodies are developed at least 15 months prior to any clinical evidence of BOS. This lag period between the development of anti-HLA antibodies and the onset of BOS gives us an opportunity to intervene to delay and/or prevent the development of BOS.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Lung transplant recipient.
排除标准
- •Pregnant women,
- •Prisoners, AND
- •Anyone who is unable or unwilling to consent to this study.
结局指标
主要结局
The primary efficacy event is the change in pulmonary function testing values (FEV1).
时间窗: Lung function is monitored at regular intervals. Patients will be followed for five years.
次要结局
- Secondary efficacy measurements include allograft and patient survival, incidence of BOS and Obliterative bronchiolitis.(The subjects are monitored at regular intervals. Patients will be followed for five years.)
研究者
相似试验
已完成
不适用
The Development of a Human Model of Respiratory Syncytial Virus InfectionRespiratory Syncytial Virus InfectionsRespiratory Viral InfectionsNCT01349543Imperial College London40
已完成
不适用
Humoral and cellular immune response of the adaptive immune system after vaccination or natural COVID infectioImmune response following vaccinationDRKS00026029niversitätsmedizin Göttingen425
已完成
不适用
Phase II study of Histocompatibility Leukocyte Antigen (HLA)-A*2402 Restricted Peptide Vaccine Therapy for maintenance of Patients With Neovascular Maculopathyeovascular MaculopathyJPRN-UMIN000006372Department of Ophthalmology, Osaka University Medical School120
尚未招募
不适用
Study to the humoral and cellular immuneresponse after influenzavaccination in patients with metastasized RCC or GIST treated with a tyrosine kinase inhibitor(sunitinib or sorafenib)kidney cancer10038363GISTNL-OMON32710niversitair Medisch Centrum Sint Radboud75
终止
1 期
Pilot Study of partially Human Leucocyte Antigen (HLA)-mismatched stem cell infusions after chemotherapy for acute myeloid leukaemia in patients over the age of 60.ACTRN12613000337774St Vincent's Hospital, Sydney12