Effect of Repetitive Transcranial Magnetic Stimulation in Vascular Parkinsonism
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Unified Parkinson's Disease Rating Scale (UPDRS) part III-motor part (Number 18 ~31 of UPDRS)
研究概览
简要总结
Vascular parkinsonism (VP), parkinsonism resulting from ischemic cerebrovascular disease, was suggested in 1929. The main features are wide-based gait, postural instability, and falls, which make patients with VP frustrated. Currently, the treatment is challenging.
Transcranial magnetic stiumation is a noninvasive procedure using electromagnetic induction to stimulate brain, and repetitive transcranial magnetic stiumation (rTMS) can selectively change brain activity to enhance desired effects. The aim of this study is to explore the therapeutic effect of rTMS for the VP.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Vascular parkinsonism
- •age 18 and older
排除标准
- •pregnant or any, other medical, surgical, neurological or psychiatric conditions
- •other restrictions which prevent you from undergoing TMS recording, such as; surgically or traumatically implanted foreign bodies such as a pacemaker, an implanted medication pump, a metal plate in the skull, or metal inside the skull or eyes (other than dental appliances or fillings), and/ or heart/cardiac lines
- •any past or current history of seizure disorder or epilepsy
- •unable to give informed consent
研究组 & 干预措施
Real rTMS Supplementary motor area
Real rTMS will be applied over the supplementary motor area
干预措施: Real rTMS Supplementary motor area (Device)
Sham rTMS Supplementary motor area
Sham rTMS will be applied over the supplementary motor area
干预措施: Sham rTMS Supplementary motor area (Device)
结局指标
主要结局
Unified Parkinson's Disease Rating Scale (UPDRS) part III-motor part (Number 18 ~31 of UPDRS)
时间窗: 2 days
Motor functions will be checked using UPDRS. Each item of the motor part ranges from 0 to 4 (0 means normal, 4 means worst condition). Total sum will be calculated.
次要结局
- The total number of steps during the stand-walk-sit (SWS) test(2 days)
- Freezing episodes of gait trajectory(2 days)
- Finger tapping test with right hand(2 days)
- The completion time during the SWS test(2 days)
- Patient and Clinical Global Impression Scale(2 days)