Dose inidividualization of antimicrobials based on population pharmacokinetic analysis in patients undergoing blood purification therapy - Dose inidividualization of antimicrobials based on population pharmacokinetic analysis in patients undergoing blood purification therapy

In vancomycin-administered-patients with continuous blood purification therapy, we identified reduced urine output (RUO, <0.5 ml/kg/h) and effluent flow rate were the factor for the vancomycin clearance. Using the pharmacokinetic model, The compliance rate for therapeutic trough concentration by the Bayesian estimation was higher (87.0%) than that by a conventional method (53.8%, P = 0.046). The variance was lower (11.5) by the Bayesian estimation than by a conventional method (50.5, P = 0.003).