Comparison Between Epinephrine and Clonidine as Adjuvants to Lidocaine in Ultrasound Guided Axillary Brachial Plexus Block.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 主要终点
- Onset of Sensory Block
研究概览
简要总结
Adjuncts to local anaesthetics for the peripheral nerve blocks such as epinephrine, clonidine and opioids have been widely used to enhance quality, duration of anaesthesia and postoperative analgesia. Clonidine, an α2-adrenergic agonist, when combined with local anaesthetics in axillary brachial plexus block has shown to decrease block onset time and prolong the duration of anaesthesia.
We propose to compare the effects of combining both adjuvants to 20 mL of lidocaine 2% on the onset of ultrasound guided axillary brachial plexus block.
详细描述
Using a 20 mL lidocaine 2% when combined with epinephrine 1:200 000 and clonidine 1 µg/kg will shorten the onset time of sensory block when compared to lidocaine 2% with epinephrine 1:200 000 alone in ultrasound guided axillary brachial plexus block for elective upper limb surgeries.
It is a prospective, randomized, observer blinded study. With institutional ethical approval and having obtained written informed consent from each, 24 patients will be studied.
Randomisation and blinding:
Using a computer generated and sealed envelope technique, 24 patients will be randomized in to one of two groups to receive ultrasound guided axillary brachial plexus block.
Group 1:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients age >18 years
- •Undergoing elective upper limb (forearm, wrist or hand) surgery.
排除标准
- •Contraindications to regional anaesthesia
- •Hypersensitivity to amide local anaesthetics.
- •Chronic pain
- •Language barrier
- •Neuromuscular disorders or peripheral neuropathy
- •H/o postural hypotension or autonomic dysfunction.
- •Patients with a known sensitivity for local anaesthetics
- •Body mass index > 35
- •History of hepatic and renal insufficiency
- •Pregnancy
- •Cognitive or psychiatric disorder
- •Cardiac conduction abnormality.
- •Anti arrythmic or adrenergic medications.
结局指标
主要结局
Onset of Sensory Block
时间窗: 1 day
Time taken for onset of sensory axillary brachial plexus block
次要结局
- Onset of Motor Block.(1 day)
- Duration of Sensory and Motor Block(1 day)
研究者
Dr Anil Ranganath
Dr (Fellow in Regional Anaesthesia)
Cork University Hospital