Studies on the Physiological Meaning of Flow-mediated Constriction, Flow-mediated Dilatation and Vasomotion/Flowmotion: Circadian Variability and Role of the Sympathetic Nervous System.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Change in FMD in response to sympathetic activation
研究概览
简要总结
The purpose of this study is to determine whether interventions aimed at increasing sympathetic tone modify endothelial function measures as assessed by the measurement of flow-mediated dilation (FMD) and constriction (FMC). The investigators hypothesize that the three interventions under study will increase FMC while causing a blunting in FMD.
Further, the investigators plan to study the circadian variability of FMC and FMD. The investigators hypothesize a peak of FMD in the late hours of the day and a peak of FMC in the early hours.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy volunteers with no cardiovascular risk factor, no current disease, normal laboratory parameters and ECG.
排除标准
- •any active disease
研究组 & 干预措施
Myogenic activation
Subjects will undergo endothelial function assessment at rest and, after a 45 minutes pause, 1 minute after begin of myogenic activation
干预措施: Myogenic activation (Procedure)
Cold pressure test
Subjects will undergo endothelial function assessment at rest and, after a 45 minutes pause, 1 minute after begin of cold pressure test
干预措施: Cold pressure test (Procedure)
mental stress
Subjects will undergo endothelial function assessment at rest and, after a 45 minutes pause, 1 minute after begin of mental stress
干预措施: Mental stress (Procedure)
结局指标
主要结局
Change in FMD in response to sympathetic activation
时间窗: Change in FMD before versus 1 Minute after begin of intervention
Flow-mediated dilation will be measured at rest and during each of the interventions.
次要结局
- Change in FMC during sympathetic activation(Change in FMC before versus 1 minute after begin of each intervention)
研究者
Tommaso Gori
Professor
Johannes Gutenberg University Mainz