Association of MMP-2 and MMP-3 Polymorphisms With 12-Month Radiographic Healing After Nonsurgical Root Canal Treatment in Chronic Apical Periodontitis: A Prospective Clinical Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 50
- 主要终点
- Radiographic Periapical Healing
研究概览
简要总结
This prospective randomized clinical study will investigate the association between MMP-2 and MMP-3 gene polymorphisms and radiographic healing outcomes following nonsurgical root canal treatment in patients with chronic apical periodontitis. A total of 50 patients will undergo standardized endodontic treatment and will be followed for 12 months. Genotyping will be performed using baseline DNA samples, and periapical healing will be assessed using the Periapical Index (PAI). The relationship between genetic variations and treatment outcomes will be analyzed to determine whether host-related genetic factors influence healing patterns after root canal therapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Single-rooted teeth
- •PAI score ≥ 3
- •Fully developed root apices
- •Periodontal probing depth less than 5 mm
- •Indication for primary nonsurgical root canal treatment
排除标准
- •Previous endodontic treatment in the selected tooth
- •Diagnosis of symptomatic apical abscess
- •Presence of root fracture or internal/external resorption
- •Use of systemic antibiotics within the previous 4 weeks
- •Analgesic intake within 48 hours before treatment
- •Ongoing immunosuppressive therapy
- •Pregnancy or breastfeeding
研究组 & 干预措施
Standardized Root Canal Treatment
Participants will undergo standardized nonsurgical root canal treatment using a uniform clinical protocol. Radiographic healing outcomes will be evaluated at 12 months, and results will be analyzed in relation to MMP-2 and MMP-3 gene polymorphisms.
干预措施: Nonsurgical Root Canal Treatment (Procedure)
结局指标
主要结局
Radiographic Periapical Healing
时间窗: 12 months after treatment
The primary outcome will be radiographic healing assessed using the Periapical Index (PAI) scoring system on standardized periapical radiographs.
次要结局
- Association Between MMP Genotypes and Healing Outcomes(Baseline (genotyping) and 12 months after treatment)
研究者
Ayşe Tuğba Eminsoy Avcı
Lecturer
TC Erciyes University