Evaluating Changes of Brain Networks and White Matter Fibers by fMRI and DTI After Treatments in Patients With Germ Cell Tumors in the Basal Ganglia
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Changes of white matter fibers measured by DTI after treatments.
研究概览
简要总结
BOLD-fMRI and DTI scans are performed to patients with germ cell tumors in the basal ganglia before and after treatments. The changes of the MRI and muscle strength of patients during treatments are evaluated, and the association between these two are investigated.
详细描述
Primary intracranial germ cell tumors are a specific entity of brain tumors with a variety of histological types and different degrees of malignancy. Intracranial GCTs make up 11.2% - 15.3% of primary intracranial tumors in Asian children compared with 3.6% in the US. And tumors located at the basal ganglia is much rarer.
The investigators realize that most of patients with tumors at this location are involved with motor disfunction. And after treatments, some patients get relieved dramatically, but some others failed to get similar outcomes. To better understand the mechanism causing this difference of treatment outcomes, the investigators perform BOLD-fMRI and DTI scans to patients with germ cell tumors in the basal ganglia before and after treatments. The changes of the fMRI and muscle strength of patients during treatments are evaluated, and the association between these two are investigated.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 3 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age ≥3 years;
- •no history of brain radiotherapy;
- •no other known cause of movement and cognitive impairment;
- •no contraindications to the magnetic resonance imaging (MRI) scan;
排除标准
- •patients can not tolerate MR scan;
- •head motion is greater than 3 mm during functional MRI scanning.
结局指标
主要结局
Changes of white matter fibers measured by DTI after treatments.
时间窗: The DTI scans are performed along with the fMRI scans.
The white matter fibers damaged by tumor are evaluated by FA and MD value.
Changes of brain networks measured by BOLD-fMRI after treatments.
时间窗: The fMRI scans are performed: (1) before treatments in one week, (2) before radiotherapy in one week, (3) after radiotherapy in one week, (4) one year after radiotherapy.
The brain networks during treatments are compared by functional connectivity.
次要结局
- Changes of muscle strength after treatments.(The muscle strength evaluation are performed at the same day before the fMRI scans.)