Characterization of Natural IL-6 Inhibition in Healthy Individuals
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Inflammatory markers
研究概览
简要总结
The aim of the project is to investigate whether or not there are any difference in cardiometabolic outcomes in individuals with high or low levels of c-aAb against interleukin-6 (IL-6).
The study is the first to investigate individuals with extreme amounts of c-aAb levels against IL-6 and to contribute with knowledge on a possible new phenotype.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Fulfill Danish blood donor criteria
- •Have extreme amounts of IL-6 c-aAb or matched as control (low amounts of IL-6 c-aAb)
排除标准
- •Failure to fulfill Danish blood donor criteria
结局指标
主要结局
Inflammatory markers
时间窗: Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery
IL-6 plasma levels, plasma IL-6 c-aAb levels
Whole-body glucose metabolism
时间窗: Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery
Plasma levels of: Insulin
Cardiovascular risk markers
时间窗: Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery
Lipids
Difference in exercise response
时间窗: Measurements over a two-hour cycling test, and one hour of recovery
2-hour Lactate
Metabolic response during exercise
时间窗: Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery
2-hour glucose
Metabolic assessment of the liver
时间窗: An MRI-scanning withinn four weeks of the oral glucose tolerance test
Liver fat content from MRI-scanning, and HOMA-IR
次要结局
未报告次要终点
研究者
Torben Hansen
Professor
University of Copenhagen