Comparative evaluation of Antibacterial efficacy of Immunoglobulin Y (IgY) toothpaste, Fluoridated toothpaste and non-Fluoridated toothpaste on salivary Streptococcus mutans - A double-blind, Randomized Controlled Trial
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Bacterial count of Streptococcus mutans
研究概览
简要总结
Dental cariesis a multifactorial disease which mainly results from reactions among oral flora, susceptible host and diet. Streptococcus mutans and Lactobacillusare the two main cariogenic bacteria causing dental caries. Although Fluoride plays an important role in anti-caries effect, its role is only limited. Hence a newer method of passive immunization was introduced to act against streptococcus mutans. This passive immunization with immunoglobulin y obtained from yolk of chicken egg is highly active against streptococcus mutans. This study aims to assess and compare the Antibacterial efficacy of Immunoglobulin Y (IgY) toothpaste, Fluoridated toothpaste and non-Fluoridated toothpaste on salivary Streptococcus mutans.
研究设计
- 研究类型
- Interventional
- 分配方式
- Other
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 12.00 Year(s) 至 15.00 Year(s)（—）
- 性别
- All
入选标准
- •12 to 15 years of age Both male and female are included Caries active individuals (Caries active individuals are those who have at least one carious tooth surface) Subjects who are willing to follow the instructions given during the course of study.
排除标准
- •Subjects who have received antibiotics 2 weeks prior to the study.
- •Subjects using other oral hygiene aids like Mouthwash, dental floss, water floss.
- •Subjects with systemic illness.
- •Subjects with history of allergy to egg.
结局指标
主要结局
Bacterial count of Streptococcus mutans
时间窗: 45 days after using respective toothpaste
次要结局
- Decrease in colony count of bacteria Streptococcus mutans(15th day after using respective toothpaste)
研究者
Dr Angel Abisha S
Best Dental Science College