NCT05406297已完成不适用
Impact of Trimethylamine N-oxide (TMAO) Serum Levels on Index of Microcirculatory Resistance (IMR) in Patients Diagnosed With ST-Elevation Myocardial Infarction (STEMI)
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Index of microcirculatory resistance
研究概览
简要总结
Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite of dietary choline, L-carnitine, and phosphatidylcholine-rich foods. On the basis of experimental studies and patients with prevalent disease, elevated plasma TMAO may increase risk of atherosclerotic cardiovascular disease (ASCVD). However, to our knowledge, no data is available on its impact on coronary microcirculation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient diagnosed with STEMI
- •Availability of non- left anterior descending artery (LAD) non culprit lesion, which is planned for a staged Percutaneous coronary intervention (PCI)
排除标准
- •patient undergoing cardiopulmonary resuscitation;
- •patients with a history of old myocardial infarction or history of coronary artery bypass grafting (CABG) or Percutaneous coronary intervention PCI
- •Patients with signs of chronic infection, prolong usage of corticosteroids or compromised immune system
- •patients had thrombolysis before primary Percutaneous coronary intervention (pPCI)
- •had contraindication of adenosine triphosphate (ATP);
- •had a history of liver or renal function dysfunction
- •Patients with dementia
- •Patients being referred to CABG after primary PCI
- •unable to provide informed consent;
- •had pregnancy or life span < 1 year.
- •Presence of sever structural valvular heart disease
- •Presence of significant left main disease
- •Unability to measure the index of microcirculatory resistance due to (death or retraction from the study ...etc)
- •Inability to perform successful PCI
结局指标
主要结局
Index of microcirculatory resistance
时间窗: 3 months
The index of microcirculatory resistance (IMR) will be detected using PressureWire™ X Guidewire
次要结局
- major adverse cardiovascular events (MACE)(up to 1 year)
- Left ventricular ejection fraction(3 months)
研究者
Ali Aldujeli
Cardiovascular disease consultant
Lithuanian University of Health Sciences
研究点 (1)
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