Prospective randomized multicenter study comparing immediate multivessel revascularization by PCI versus culprit lesion PCI with staged non-culprit lesion revascularization in patients with acute myocardial infarction complicated by cardiogenic shock - CULPRIT-SHOCK

niversity of Lubeck0 个研究点目标入组 40 人开始时间: 待定最近更新: 2024年4月23日

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•Cardiogenic shock complicating acute myocardial infarction (STEMI or NSTEMI) with
•obligatory:;1. Planned early revascularization by PCI;2. Multivessel coronary artery disease defined as >70% stenosis in at least 2 major
•vessels (>=2 mm diameter) with identifiable culprit lesion;3. a Systolic blood pressure <90 mmHg for >30 min or
•b catecholamines required to maintain pressure >90 mmHg during systole and;4. Signs of pulmonary congestion;5. Signs of impaired organ perfusion with at least one of the following criteria
•a) Altered mental status
•b) Cold, clammy skin and extremities
•c) Oliguria with urine output <30 ml/h
•d) Serum-lactate >2.0 mmol/l;6. Informed consent

•1. Resuscitation >30 minutes;2. No intrinsic heart action;3. Cerebral deficit with fixed dilated pupils (not drug-induced);4. Need for primary urgent bypass surgery (to be determined after diagnostic angiography);5. Single vessel disease;6. Mechanical cause of cardiogenic shock;7. Onset of shock >12 h;8. Massive lung emboli;9. Age >90 years;10. Shock of other cause (bradycardia, sepsis, hypovolemia, etc.);11. Other severe concomitant disease with limited life expectancy <6 months;12. Pregnancy;13. Known severe renal insufficiency (creatinine clearance <30 ml/kg)

发起方

niversity of Lubeck