Biological Biomarkers in MOMS Partnership
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Telomere Length
研究概览
简要总结
The investigators propose to evaluate the potential utility of stress-related biomarkers obtained via dried blood spots (DBS) and retinal scans by collecting new data from mothers and children within the New Haven MOMS Partnership, a well-established community-partnered research setting. The proposed research could greatly advance the application of stress-related biomarkers within community-based research by increasing our understanding of how stress, trauma, and depression influence biology in childhood and adulthood, as measured using minimally-invasive approaches.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •English-speaking adult mothers (age 21 or older) of at least one biological child mothers must be able to answer three verification questions to confirm they are the biological parent of their child
排除标准
- •Non-english speakers
- •Women not able to provide informed consent and with no biological children
- •Mothers under the age of 21
结局指标
主要结局
Telomere Length
时间窗: At baseline-After 90 minutes
Telomere length will be measured using an adapted method of the Cawthon Telomere Assay
Number of Mother-Child Dyads Who Complete Assessments & Biological Samples
时间窗: End of study (approximately 5 years)
Feasibility outcome
Advanced Glycation End Products (AGEs)
时间窗: At baseline-After 90 minutes
AGEs or (advanced glycation endproducts) will be measured using a painless non- invasive retinal scanning device that measures autofluorescence of the crystalline lens of the eye
次要结局
未报告次要终点