NCT00311259Unknown不适用
Melatonin Treatment and Inflammation, Oxidative Stress and Autonomic Function in Connection With Surgery
University Hospital, Gentofte, Copenhagen1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2006年5月最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 1
研究概览
简要总结
The purpose of this study is to determine whether treatment with melatonin can reduce cell damage and inflammation in connection with laparoscopic gall bladder surgery.
详细描述
Laparoscopic gall bladder surgery is connected with changes in the body resulting in cell damage and inflammation. Melatonin is a hormone produced in brain and regulate sleep rhythm, temperature, production of other hormones and function of organs. Furthermore melatonin can modify cell damage and inflammation. After surgery the production of melatonin is disturbed. The purpose of this study is therefore to determine whether treatment with melatonin can reduce cell damage and inflammation in connection with laparoscopic gall bladder surgery.
研究设计
- 研究类型
- Observational
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •indikation for laparoscopic cholecystectomy
- •women between 18 and 70 years old
排除标准
- •acute cholecystectomy
- •pancreatitis
- •renal insufficient
- •well-known liver insufficient
- •cardiovascular disease (arrhythmia, well-known ischaemic heart disease)
- •drug therapy (digoxin, Ca-antagonist, amiodaron, beta-blocker)
- •anticoagulation therapy (marevan and marcoumar)
- •praeoperative therapy with opioid, anxiolytica and hypnotica)
- •well-known sleep disease
- •endocrine disease in drug therapy (diabetes mellitus, thyroid disease)
- •daily alcohol consumption (more than 5 drinks)
- •bad compliance (language difficulty, mental problems etc.)
- •pregnancy and breast-feeding
- •lack of written consent
研究者
研究点 (1)
Loading locations...
相似试验
尚未招募
不适用
Clinical Trial for the Evaluation of Melatonin in the Treatment of Pressure UlcersPressure UlcerNCT06421454Fundacion Rioja Salud50
已完成
1 期
Melatonin in Healthy VolunteersSepsisNCT01724424University of Aberdeen20
已完成
不适用
The Influence of Melatonin Supplementation in the Group of Persons Performing Competitive Sport.AntioxidantsOxidative StressInflammationLipid PeroxidationNCT03505411Nicolaus Copernicus University81
尚未招募
1 期
To explore the treatment of psoriasis with sleep disorder by cooling blood and calming nerves: a randomized controlled trialITMCTR2100005257Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine
已完成
2 期
Melatonin and Cardiac Outcome After Major SurgeryAortic AneurysmNCT00315926University Hospital, Gentofte, Copenhagen52