Mindful Exercise Baduanjin Versus Brisk Walking for Cognitive Function in Patients With Schizophrenia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 63
- 试验地点
- 2
- 主要终点
- Change scores of 6-minute walk test
研究概览
简要总结
The current study intends to recruit participants with schizophrenia for the practice of Baduanjin, brisk walking, and health education after enrollment. The study also including a maintenance program. Cognitive and physical function assessments will be conducted before, after, and during follow-up tests. The research hypothesis posits that both Baduanjin and brisk walking will confer beneficial effects on various aspects of cognitive and physical functions.
详细描述
Cognitive function deficits are core features in patients with schizophrenia. These deficits need active intervention to prevent functional decline. Baduanjin and brisk walking show promise as interventions in patients with schizophrenia. This study investigated the effects of Baduanjin exercise versus brisk walking in patients with schizophrenia.
This study will be a single-blind, 3-arm, parallel, randomized controlled trial.
A total of 72 patients with schizophrenia will be enrolled and randomly assigned to the Baduanjin group, brisk walking group or control group. The intervention group will practice Badunjin exercise. While participants in brisk walking group will receive brisk walking at the same duration. The controls will watch videos that are not aimed at improving physical exertion. Maintenance programs will also be conducted for participants to encourage practicing in exercise after intervention. All group will undergo evaluation at three time points: baseline, immediately after intervention and 4-week follow up after intervention. The primary outcome will be cognitive function and physical function. Secondary outcomes will include mood, sleep quality, and quality of live.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Having a diagnosis of schizophrenia according to the DSM-
- •Who will be above 20-65 years of age .
- •Having a stable mental status without shift in medication and keep in same dose for at least one month.
- •Being able to walk independently for 50 meters.
排除标准
- •Serious physical conditions that will impede participation, such as cardiovascular disease, musculoskeletal disease or pulmonary system disease.
- •Visual or auditory impairment that precludes completion of assessment.
- •Acute psychosis requiring hospitalization.
- •Presence of severe withdrawal or profound cognitive disability that cause difficulties in following instructions.
结局指标
主要结局
Change scores of 6-minute walk test
时间窗: Baseline, immediate after treatment, 4-week follow up
This test evaluates cardiovascular fitness and walking speed.
Change scores of 30-second chair stand test
时间窗: Baseline, immediate after treatment, 4-week follow up
This test evaluates muscular endurance of lower-extremities.
Change scores of Timed up-and-go test
时间窗: Baseline, immediate after treatment, 4-week follow up
This test evaluates functional mobility, agility and balance
Change scores of dual task Timed up-and-go test (manual)
时间窗: Baseline, immediate after treatment, 4-week follow up
This test requires carry a cup of water 3 cm from the top of the cup while performing the Timed up-and-go test. It evaluates dual task performance.
Change score of the Brief Assessment of Cognition in Schizophrenia (BACS)
时间窗: Baseline, immediate after treatment, 4-week follow up
BACS is a battery of cognition tests that measure verbal memory, working memory, motor speed, verbal fluency, attention and processing speed, and executive function.The BACS is comprised of seven subtests: (1) the List Learning Test, (2) Digit Sequencing Test, (3) Token Motor Test, (4) Category Instance Test, (5) Controlled Oral Word Association Test, (6) Symbol Coding, and (7) Tower of London Test.
Change scores of dual task Timed up-and-go test (cognitive)
时间窗: Baseline, immediate after treatment, 4-week follow up
This test combine serial three counting and Timed up-and-go test simultaneously. It evaluates dual task performance.
次要结局
- Change score of Depression, Anxiety Stress Scales-21 (DASS-21)(Baseline, immediate after treatment, 4-week follow up)
- Change score of Pittsburg Sleep Quality Index(Baseline, immediate after treatment, 4-week follow up)
- Change score of Depression, Anxiety Stress Scales-21 (DASS-21)(Baseline, immediate after treatment, 4-week follow up)
- Change score of Pittsburg Sleep Quality Index(Baseline, immediate after treatment, 4-week follow up)
研究者
Chen Chyi-Rong
Occupational therapist
Chang Gung Memorial Hospital