NCT01161745已完成不适用
PD-1/PD-L1 Pathway in T Lymphocyte Apoptosis and Monocyte Dysfunction in Septic Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 39
研究概览
简要总结
The investigators want to identify that whether PD-1/PD-L1 pathway will change in human sepsis, and whether PD-1/PD-L1 pathway play an important role in sepsis induced immunosuppression.
详细描述
First, we will detect PD-L1 expression on PBMC of septic patients and healthy controls.
Second, blockade of PD-1/PD-L1 pathway in vitro and stimulate with some biomolecules and then analyze the PBMC function and apoptosis by flow cytometry.
Then, compare with healthy controls and find the differences.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients who develop sepsis
排除标准
- •patients with cirrhosis or renal dysfunction
- •patients with dyscrasia
- •patients with autoimmunity diseases
- •patients with severe cardiac and pulmonary diseases
- •patients with hematological diseases
- •patients with diabetes mellitus
- •patients with malignant tumors
研究者
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