NCT03899974已完成不适用
Metabolic Effects of High-amylose Wheat-based Breads in Overweight Individuals
Federico II University2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2018年3月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- 2-hours blood glucose response
研究概览
简要总结
The amylose-amylopectin ratio influences starch properties. A higher amylose content is associated with slower starch digestion thus reducing the postprandial plasma glucose response and improving the overall postprandial metabolism. So far, limited evidence is available on the metabolic effect of wheat-based foods rich in amylose. This randomised controlled study investigated the acute metabolic effects of amylose-rich wheat-based breads in overweight subjects focusing on potential mechanisms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Overweight/obese
- •18-70 years
排除标准
- •age <18 and >70 years;
- •fasting triglycerides ≥400 mg/dl;
- •fasting cholesterol >270 mg/dl;
- •cardiovascular events (myocardial infarction or stroke) during the 6 months prior to the study
- •established diabetes mellitus or any chronic disease
- •renal and liver failure (creatinine >1.7 mg/dl and transaminases >2 times than normal values, respectively)
- •anaemia (Hb <12 g /dl)
结局指标
主要结局
2-hours blood glucose response
时间窗: over 2 hours after the test meal
incremental area under the curve
次要结局
- 2-hours blood insulin response(over 2 hours after the test meal)
- 4-hours blood glucose response(over 4 hours after the test meal)
- 4-hours blood insulin response(over 4 hours after the test meal)
- glucose response(over 2 hours after the standard meal)
- intestinal fermentation(over 4 hours after the test meal)
研究者
rivellese angela
Full Professor
Federico II University
研究点 (2)
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