Influence of Domperidon on the Experience of Emotions, Brain and Bodily Activity
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Brain responses to emotions
研究概览
简要总结
The study will examine the influence of domperidon (20mg) on brain and hebavioral responses to emotional stimuli (videos) using fMRI
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Sequential
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Domperidon
Participants recieve 10mg of Domperidon, 45 minutes before the start of the experiment
干预措施: Domperidon (Drug)
Placebo
Participants recieve a placebo pill, 45 minutes before the start of the experiment
干预措施: Placebo (Drug)
结局指标
主要结局
Brain responses to emotions
时间窗: 1-3 hour after drug administratrion
fMRI brain responses to emotional videos comparing placebo vs domperidon condition. Specifically: dampened brain response to disgust and high arousing videos in domperidon condition
Body (stomach, heart, skin conductance) response to emotions
时间窗: 1-3 hour after drug administratrion
Physiological responses to emotional videos comparing placebo vs domperidon condition. Specifically: Reduction in Tachyhastria for disgust and high arousing videos in domperidone condition
Behavioral responses to emotions
时间窗: 1-3 hour after drug administratrion
Changes in subjective reports to emotional videos comparing placebo vs domperidon condition. Specifically: Reduction in disgust and arousal ratings to disgust and high arousing videos
次要结局
未报告次要终点
研究者
Prof. Dr. Soyoung Q Park
Prof. Dr.
German Institute of Human Nutrition