Postoperative Pain After Laparoscopic Cholecystectomy After Anesthesia With Isoflurane, Desflurane, Sevoflurane or Propofol
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Pain Measured on Verbal Scale of 0-10
研究概览
简要总结
To the investigators' knowledge, no study has looked at differences in postoperative pain when comparing maintenance of anesthesia with isoflurane, desflurane, sevoflurane, and propofol in laparoscopic cholecystectomy. The investigators' hypothesis is that total intravenous anesthesia with propofol will lead to less postoperative pain in the first 24 hours after laparoscopic cholecystectomy when compared to maintenance of anesthesia with isoflurane, desflurane or sevoflurane.
PURPOSE
To find out if maintenance of anesthesia with propofol leads to less postoperative pain after laparoscopic cholecystectomy when compared to maintenance of anesthesia with isoflurane, desflurane, or sevoflurane.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient ages 18-64
- •American Society of Anesthesiology Physical Status I, II or III
- •Inpatients scheduled to undergo laparoscopic cholecystectomy at Ben Taub General Hospital
排除标准
- •Open cholecystectomy - excluded due to increased levels of pain in open procedures
- •Scheduled for ambulatory surgery
- •Renal dysfunction (Serum Cr > 1.2) - excluded due to potential altered metabolism of anesthetic and pain medications
- •Allergy to any of the study medications or anesthetic agents
- •Chronic opioid analgesic use at home - excluded due to potential difficulty in assessing pain caused by the procedure alone
- •Patient inability to properly describe postoperative pain to investigators (language barrier, dementia, delirium, psychiatric disorder)
- •Patient or surgeon refusal
研究组 & 干预措施
Desflurane
General Anesthesia with Desflurane
干预措施: Desflurane (Drug)
Sevoflurane
General Anesthesia with Sevoflurane
干预措施: Sevoflurane (Drug)
Isoflurane
General Anesthesia with Isoflurane
干预措施: Isoflurane (Drug)
Propofol
General Anesthesia with Propofol
干预措施: Propofol (Drug)
结局指标
主要结局
Pain Measured on Verbal Scale of 0-10
时间窗: 24 hours
Pain measured on verbal scale of 0-10, with 0 being absolutely no pain, and 10 being the worst pain in that subjects life.
次要结局
未报告次要终点
研究者
Jaime Ortiz
Assistant Professor of Anesthesiology
Baylor College of Medicine