Early Detection & Intervention of Cerebral Palsy in Ireland
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,500
- 试验地点
- 5
- 主要终点
- Standardised Approach to Assessing infant at risk of CP
研究概览
简要总结
Cerebral palsy (CP) is the most common lifelong physical disability. It is defined as a non-progressive disorder of movement originating from neural lesions in the perinatal period, and is associated with a wide range of common comorbidities in many individuals. These include problems speaking, hearing, seeing, thinking, feeding and controlling their bladder. People with CP often have additional challenges such as behavioural and emotional issues, pain, and poor sleep. Many of these challenges respond well to intervention in early childhood, as brain plasticity is at its greatest in the first 2 years of life. However, in most clinical settings, the age for diagnosis of CP is between 24 to 29 months, after this window of neurodevelopmental opportunity.
This project will aim to improve the Early Detection of Cerebral Palsy in Ireland. This will be achieved by implementing an evidence-based approach to follow-up of High risk infants.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 40 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Legal guardians must be able and willing to give written informed consent and to comply with the requirements of this study protocol.
- •All infants considered high risk for cerebral palsy and neuro-developmental impairment will be eligible, specifically including:
- •All preterm infants born ≤32 weeks Post Menstrual Age or ≤1500 gm birth weight
- •All encephalopathic infants
- •Neurological risk factors (e.g., injury/malformation on neuroimaging, persistently abnormal neurological exam)
排除标准
- •Death prior to discharge from the neonatal unit.
结局指标
主要结局
Standardised Approach to Assessing infant at risk of CP
时间窗: 5 years
To establish a standardised approach to assessing infants at risk of CP in High Risk Follow-up Clinics across Ireland.
Reduce the age of CP diagnosis in Ireland.
时间窗: 5 years
Reduce the age of diagnosis of cerebral palsy in Ireland to less than 12 months of age by using evidence based standardised motor and neurological assessments at set time points.
次要结局
未报告次要终点