Enhancing the efficacy of tDCS by nicotinergic stimulation in schizophrenia - NicStim

Klinikum der Universität München, Campus Großhadern0 个研究点目标入组 34 人开始时间: 2017年12月29日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•competent male and female participants between 18 and 65 years old who meet the diagnostic criterias for an schizophrenia diagnosis Statistical Classification of Diseases and Related Health Problems (ICD-10)
•- stable antipsychotic treatment with one antipsychotic drug. Conformity with treatment guidelines must be given. If required a combination of two antipsychotic drugs is possible as long as total dosis is under 1000mg CPZ
•- Severity of psychopathology is measured with PANSS und must be under a total of 75 points
•- no severe depressive symptoms CDSS<8
•- negative pregnancy test for women
•- usage of contraceptive methods (CTFG 2014)

•- positive pregnancy test for women
•- acute suizidal tendencies or danger of harming others
•- severe neuronal or internistic injuries/disease
•- schizophrenia which is resistant to Treatment and Treatment with clozapin
•- known non-compliance regarding intake of medication
•- beginning of treatment with antidepressiva, benzodiazepine or mood stabilisers during intervention. Stable medication with the mentioned medication can maintain unchanged.
•- addiction to alcohol or substances 6 months prior to intervention (not including coffein). During the Intervention the intake of addictive substances is not allowed (not including coffein)
•- epileptic attacks in the past
•- characteristical potentials of epilepsy in the EEG
•- positive drug Screening measured with laboratory urine and cdt test
•- creatinine outside of normal range
•- intolerance to study medication or tDCS stimulation
•- Patient can not give consent or is under medical treatment against his/her will
•- no sufficient knowledge of german language
•- state of health which is resistent to Treatment or was never treated before

发起方

Klinikum der Universität München, Campus Großhadern