Corticosteroids and Cataracts : Prospective Study of the Impact of Systemic Corticosteroid Therapy on Lens Transparency Evaluated by Scheimpflug Photography and Quantification of Lens Autofluorescence.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Cataracts on Ophthalmologist's Examination
研究概览
简要总结
Corticosteroid therapy is usually regarded as a risk factor for the development of posterior subcapsular cataracts but prospective studies on this topic and accurate assessment of this potential adverse effect are lacking. We will evaluate changes of lens transparency after administration of systemic corticosteroid therapy for at least one year with Scheimpflug photography and quantification of lens autofluorescence.
详细描述
Corticosteroid therapy is usually regarded as a risk factor for the development of posterior subcapsular cataracts but prospective studies on this topic and accurate assessment of this potential adverse effect are lacking. We will evaluate changes of lens transparency after administration of systemic corticosteroid therapy for at least one year with Scheimpflug photography and quantification of lens autofluorescence.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patient who starts a treatment with Prednisone, Prednisolone or Methylprednisolone for an Expected time of one year at least, with normal lens autofluorescence at inclusion.
排除标准
- •Previous cataracts and abnormal increase of lens autofluorescence considering age
- •Previous elevation of intraocular pressure
- •Progressive inflammatory or non inflammatory ocular disease
- •Eye drop except artificial tears
- •Insulin dependent and non insulin dependent diabetes
- •Atopic dermatitis
- •Previous protracted corticosteroid therapy
- •Drugs known to be associated with an increased risk of cataract
结局指标
主要结局
Cataracts on Ophthalmologist's Examination
Increase of Lens Autofluorescence
Increase of Lens Density on Scheimpflug Photography
次要结局
- Potential risk factor of cataracts related to the underlying disease or the individual
- Potential effect of time allowed from the beginning of treatment, duration and dosage of corticosteroids.