Are Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Systemic Immune Inflammation Score Values Indicators for Postoperative Pain?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 2
- 试验地点
- 2
- 主要终点
- postoperative analgesic consumption
研究概览
简要总结
Postoperative pain status of patients who underwent elective laparoscopic cholecystectomy.
详细描述
Subject Researched:
Postoperative pain is a result of the inflammatory response to surgical trauma. Local inflammatory mediator response triggered by surgical incision, dissection, retraction, etc. causes an increase in nociceptor sensitivity and hyperalgesia, resulting in the perception of postoperative pain. With the acute phase response caused by surgical trauma, tissue damage is brought under control, infection is limited and the healing process begins. During the inflammatory response, the level of leukocytes in the blood also changes. Neutrophil/Lymphocyte ratio (NLR), Platelet/Lymphocyte ratio (PLR) and Systemic immune inflammation score (SII) are inexpensive and easily accessible biomarkers calculated from routine hemogram parameters and shown to be helpful in disease investigations and evaluation of treatment response. In this study, the relationship between biomarkers and postoperative pain status due to surgery will be investigated
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 18-75 years who underwent elective laparoscopic cholecystectomy.
- •Patients with ASA status1-2-3
排除标准
- •Emergency operated patients
- •Patients switched to open surgery
- •Patients allergic to tramadol
- •Those allergic to paracetamol
- •Those allergic to tenoxicam
- •Patients who cannot use the patient-controlled analgesia device
- •Those with hematological disorders
- •Those receiving immunosuppressive therapy
- •Those with inflammatory disease
- •Those with gastrointestinal tumors
- •Those with rheumatic disease
- •Those with uncontrolled diabetes
- •Those with chronic organ failure
- •Those who use corticosteroids
- •Opioid users
- •Those who have recently had an attack of cholecystitis, pancreatitis
结局指标
主要结局
postoperative analgesic consumption
时间窗: 24 hours
次要结局
- postoperative pain score(24 hours)
研究者
Senay Canikli
medical specialist (Anesthesiology and Reanimation)
Samsun University