NCT04310657Unknown不适用
mNGS Was Applied to the Study of Pathogen Identification, Precision Medication and Efficacy Evaluation of Infected Patients
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine0 个研究点目标入组 200 人开始时间: 2020年10月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 主要终点
- 28-day mortality
研究概览
简要总结
- prospectively collected the patients with the proposed infection, confirmed the infection or excluded the infection through mNGS detection combined with traditional pathogen detection methods and clinical characteristics, compared the detection performance of mNGS and traditional methods, and explored the significance of mNGS microbial map characteristics for the diagnosis/exclusion of infection; 2) real-time dynamic monitoring of the pathogen and microecology of infected patients during the targeted drug use, and evaluation of the efficacy in combination with other indicators; 3) to explore the significance of the number of pathogen sequences before the clinical withdrawal of drugs to the clinical practice.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 to 75 years old
- •expected length of stay in ICU was > 24 h
- •suspected infected patients (PSI or CPIS, qSOFA or SIRS)
排除标准
- •Pregnant and lactating women
- •Who has not signed the informed consent
- •the researchers considered that others were not suitable for the study
结局指标
主要结局
28-day mortality
时间窗: 28 days
28-day mortality
次要结局
未报告次要终点
研究者
Ruilan Wang
prof
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
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