NCT03768284已完成不适用
Genetic Analysis of Pediatric Psoriasis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 86
- 试验地点
- 1
- 主要终点
- CARD14 mutations
研究概览
简要总结
This study will ascertain approximately 150 subjects, which will include pediatric psoriasis patients diagnosed before age 12, parents not affected by psoriasis, and if a family history is indicated, up to third-degree family members. Saliva (or buccal swabs in the case of infants) will be obtained for DNA isolation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients (of any age) who developed psoriasis before 12 years of age and who have no family history of psoriasis in either parent.
- •Parents of patients who developed psoriasis before 12 years of age
- •Up to third-degree family members (first cousin, grandparent, great-grandparent) with or without psoriasis, if family history is indicated.
排除标准
- •Patients, parents, and other family member unable to give a saliva or buccal swab sample.
- •Patients, parents, and other family member unable to give written informed consent.
结局指标
主要结局
CARD14 mutations
时间窗: one year
The number of pathogenic mutations identified in CARD14 in a pediatric psoriasis cohort
次要结局
- De novo mutations(one year)
研究者
Amy Paller
Principal Investigator
Northwestern University
研究点 (1)
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