EXIST: Physical exercise to improve fitness and combat fatigue in patients with Multiple Myeloma or (non-) Hodgkin*s lymphoma after high dose chemotherapy and autologous stem cell transplantation. - EXIST

Academisch Medisch Centrum0 个研究点目标入组 125 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

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•-diagnosed with multiple myeloma in first line or or with HL/NHL in first line or first relapse, who have undergone HDC and autologous SCT 6 to 12 weeks ago or who where recently (< 8 months) treated with HDC and autologous SCT and who have completed radiotherapy or their last cycle of consolidation chemotherapy 2 to 6 weeks ago-Sufficiently recovered from the SCT and having peripheral blood recovery;
•-Age between 18 and 65 years;
•-Ability to cycle on a bicycle ergometer against a load of at least 25 Watt;
•-Ability to walk at least 100 meters independently without crutches/cains or walking frame;
•-Written informed consent.

•-tandem autologous-allogeneic stem cell transplantation
•-Severe cognitive impairment;
•-Severe emotional instability;
•-Insufficient mastery of the Dutch language;
•-Presence of extensive osteolytic lesions with risk of fracture;
•-Serious cardiopulmonary and cardiovascular conditions;
•-Other disabling comorbidity interfering with the intervention program or influencing outcome parameters (a.o. having a pacemaker , epileptic seizures and poorly regulated diabetes mellitus);
•-Severe infections;
•-Relapse/progression of disease.

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