Study of Routs of Naloxone Administration for Opioid Overdosed Patients
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- level of consciousness
研究概览
简要总结
The purpose of this study is to determine which route of administration is better for treatment of opioid overdosed patients
详细描述
In intravenous drug abusers (IDUs), as a result of previous intravenous substance abuse, the predictable difficult cannulate exist and cause the delay administration of antidote therapy. Additionally, IDUs are also at increased risk of carrying blood borne infections that could be transmitted to healthcare workers through needle stick injuries. The investigators aimed to compare intranasal administration of naloxone with intravenous route.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 15 Years 至 50 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with the range of 15-50 years old
- •Who were suspicious to opioid overdoses based on history and having clinical appearance such as miotic pupils with loss of consciousness
- •Give response to naloxone with increasing the level of consciousness
排除标准
- •Not giving response to naloxone and suspicious to have another reason for loss of consciousness
研究组 & 干预措施
Intravenous
The investigators administered intravenous naloxone for our opioid overdose patients
干预措施: Intravenous (Drug)
Intranasal
The investigators administered intranasal naloxone for treatment of our patients
干预措施: Intranasal naloxone (Drug)
结局指标
主要结局
level of consciousness
时间窗: 4 min after naloxone administration
The investigators evaluated the level of consciousness with Glasgow coma sclae 4 minutes after naloxone administration
次要结局
- blood pressure(at 4 min after naloxone administration)