NCT00627848已完成不适用
Effect of Rivastigmine on FMRI in Mild Alzheimer's Disease
Kuopio University Hospital2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2007年3月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- FMRI response in face recognition task
研究概览
简要总结
The purpose of the study is to investigate the effect of rivastigmine given as an acute dose compared to placebo and after 1 month chronic dosing on fMRI response during a face recognition task. Furthermore, the aim is to investigate whether fMRI response is correlated with long term treatment effect at 6 months and 12 months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 55 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Probable Alzheimer's disease according to the NINCDS-ADRDA criteria
- •mild disease, CDR 1
- •the clinician is planning to start anticholinesterase treatment
排除标准
- •cognitive impairment for other reason than Alzheimer's disease
- •severe depression
- •other unstable physical disease
- •medal in body prevention MRI examination, claustrophobia
- •cardiac pacemaker
- •other significant neurologic or psychiatric disease
- •contraindication for anticholinesterase treatment
结局指标
主要结局
FMRI response in face recognition task
时间窗: at baseline and at 1 mo
次要结局
- treatment response measured by ADAS-cog(at 6 month and 1 year)
研究者
Hilkka Soininen
Professor
Kuopio University Hospital
研究点 (2)
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