Hair Regrowth Following Partial Thickness Stages in Mohs Micrographic Surgery of Squamous Cell Carcinoma in Situ: A Prospective Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 15
- 主要终点
- Hair Growth measured clinically by hair density percentage compared to baseline photo
研究概览
简要总结
Participants are being approached to participate in this study because they are undergoing surgery for a skin cancer known as squamous cell carcinoma in situ (SCCIS) on the scalp. Standard surgical techniques may remove deeper structures that contain hair follicles, which can result in permanent hair loss. This study evaluates whether a modified surgical technique, known as partial thickness excision, can preserve hair growth and improve cosmetic outcomes. Participation involves minimal risk beyond the standard risks of Mohs surgery. If patients choose to participate, their surgery will be performed using this technique, and photographs will be taken over time to evaluate hair regrowth and healing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults ≥ 18 years old
- •Histologically confirmed SCCIS
- •Lesions located in the hair-bearing scalp
- •Ability to provide informed consent
排除标准
- •Invasive, poorly differentiated, or high-risk SCC features (e.g., perineural invasion)
- •Recurrent SCC at the same site
- •Prior radiation therapy to the scalp
- •Scarring alopecia or active inflammatory scalp disease at the treatment site
- •Immunosuppression that, in the investigator's judgement, increases oncologic risk
- •Use of topical minoxidil, oral minoxidil, finasteride, spironolactone, or other hair-growth promoting agents
研究组 & 干预措施
Partial Thickness Excision
Participants will receive excision of their squamous cell carcinoma in situ of the scalp via partial thickness excision (removal of epidermal and superficial dermal tissue) in an effort to preserve hair follicles and hair growth potential.
干预措施: Partial Thickness Excision (Procedure)
结局指标
主要结局
Hair Growth measured clinically by hair density percentage compared to baseline photo
时间窗: 3 and 6 months post-procedure.
To evaluate hair growth following partial thickness excision of SCCIS at 3 and 6 months post-procedure.
次要结局
- Clearance of SCCIS measured by Mohs surgeons' interpretation of margins on surgical slides.(Immediately following the final Mohs stage during the index procedure)
- Patient Satisfaction measured via patient satisfaction questionnaire(3 and 6 months post-procedure)
- Complications(2 weeks post-procedure, 3 months post-procedure, and 6 months post-procedure)
研究者
Naomi Lawrence
Principle Investigator
The Cooper Health System