Healing Effect of Ziziphus Honey on Extracted Tooth Socket in Humans by Evaluating the Levels of BMP-2 and OPN
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- levels of BMP-2
研究概览
简要总结
Ziziphus honey can improve bone healing at extracted tooth sockets in humans by increasing salivary levels of bone markers, OPN and BMP-2.
详细描述
objectives of study: To study the effects of ziziphus honey on bone healing of extracted tooth socket in humans by comparing 1) Levels of BMP-2 and OPN in experimental and control groups at different intervals and 2) By radiographically measuring RBD of extraction sockets in experimental and control groups.
Aim of study: Post extraction ridge resorption is a major concern for future tooth prosthesis or implant placement. Honey can possibly help to improve bone healing and minimize ridge resorption after extractions.
Materials and Methods
Randomized controlled trial with simple random sampling of healthy individuals will be done. Total number of 30 participants will be equally divided into experimental group and control group. After tooth extractions in both groups, ziziphus honey will be injected into extracted sockets of experimental group while control group will be left as it is. Levels of BMP-2 and OPN will be tested in saliva through ELISA technique at day 0, 3 and 7 of tooth extraction and RBD will be measured on periapical radiographs at day 3, 21 and 40 in both groups.
Keywords: Bone morphogenetic protein-2 (BMP-2), Osteopontin (OPN), Relative bone density (RBD), Enzyme linked immunosorbent assay (ELISA).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Participant)
盲法说明
Participants were not aware of the intervention used
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy patients of either gender with adult age
- •No known hypersensitivity to honey.
- •Permanent maxillary or mandibular molars (first or second molars)
排除标准
- •History of radiotherapy or chemotherapy
- •Diabetic and hypertensive patients.
- •Pregnant and lactating females.
- •Smoking or consumption of alcohol
- •Bone conditions like osteoporosis etc.
- •Patients on oral contraceptives or steroid therapy
- •Subjects taking antibiotics or NSAIDS within one week.
研究组 & 干预措施
experimental group
ziziphus honey was applied into the sockets after tooth extractions in experimental group
干预措施: ziziphus honey (Drug)
结局指标
主要结局
levels of BMP-2
时间窗: 1 week
bone morphogenetic protein-2 levels to access amount of bone healing
Relative bone density
时间窗: 40 days
bone quality confirmed on periapical radiographs in both groups
levels of OPN
时间窗: 1 week
Osteopontin levels to access amount of bone healing
次要结局
未报告次要终点
研究者
Momina khalid
Principal investigator
Postgraduate Medical Institute, Lahore