Cancer Biology of Retinoblastoma
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- Change in efficiency of reprogramming in cells with "naturally occurring" retinoblastoma mutations
研究概览
简要总结
Many children with the childhood cancer, Retinoblastoma, have surgery to remove the tumor and sometimes the entire eye. The purpose of this study is to collect the extra tissue from patients who undergo tumor removal for laboratory experiments that will help us understand not only what occurs in retinoblastoma cells but also how cells normally function. Some of these studies will include an evaluation of how cells control the way that genes are expressed, how cells "know" to become retinal cells, how cells remain retinal cells, how cells lose their identity as retinal cells, what changes make retinoblastoma cells different from normal retinal cells, and what changes make some retinoblastomas worse than others.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 5 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient must have retinoblastoma
- •Patient must be receiving biopsy, partial surgical excision of the tumor, complete excision of the tumor, or enucleation of the eye as part of their standard care.
- •Parental consent
排除标准
- •Diagnosis other than Retinoblastoma
- •No surgical sampling of tumor is planned as part of standard care
- •Parental preference to not participate.
结局指标
主要结局
Change in efficiency of reprogramming in cells with "naturally occurring" retinoblastoma mutations
时间窗: After appropriate time, e.g., 7, 10, 14 days after reprogramming
Comparison of number of reprogramming events (defined by colony formation assay and normalized for number of cell plated) as well as the time to reprogramming.
次要结局
未报告次要终点