Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Size of chalazion
研究概览
简要总结
Local injection of 5-fluorouracil into a chalazion (stye) is as effective as local injection of triamcinolone (steroid) and incision and curettage for treatment of chalazia.
详细描述
This is a prospective randomized interventional study comparing four current standard-of-care treatments for chalazia: incision and curettage, local injection of triamcinolone, local injection of 5-FU, and local injection of combination triamcinolone/5-FU.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Single or multiple chalazia in a single eyelid
排除标准
- •Chalazia present for less than one month and no previous injection or incision and curettage
研究组 & 干预措施
Incision and Curettage
A vertical incision over the area of chalazion will be done. Inflammatory material will be removed and the chalazion capsule will be excised.
干预措施: Incision and Curettage (Procedure)
Injection of Triamcinolone Acetonide
0.1 ml of triamcinolone is injected directly in the chalazion.
干预措施: Triamcinolone Acetonide (Drug)
Injection of Triamcinolone Acetonide
0.1 ml of triamcinolone is injected directly in the chalazion.
干预措施: Incision and Curettage (Procedure)
Injection of 5-fluorouracil
0.1 ml of 5-fluorouracil is injected directly in the lesion transconjunctivally.
干预措施: 5-fluorouracil Injection (Drug)
Injection of 5-fluorouracil
0.1 ml of 5-fluorouracil is injected directly in the lesion transconjunctivally.
干预措施: Incision and Curettage (Procedure)
Injection of triamcinolone/5FU mixture
0.1 ml of a 4:1 mixture of 4 parts 5-FU and 1 part triamcinolone is injected in the lesion.
干预措施: Incision and Curettage (Procedure)
Injection of triamcinolone/5FU mixture
0.1 ml of a 4:1 mixture of 4 parts 5-FU and 1 part triamcinolone is injected in the lesion.
干预措施: Triamcinolone Acetonide/5-fluorouracil mixture (Drug)
结局指标
主要结局
Size of chalazion
时间窗: 4 weeks
次要结局
未报告次要终点
研究者
Matthew Zhang
Assistant Professor of Ophthalmology
University of Washington