CTRI/2025/03/082731尚未招募2/3 期
A comparative study between oral Labetalol and oral Nifedipine in pregnancy induced hypertension
Swagata Dey1 个研究点 分布在 1 个国家目标入组 80 人开始时间: 2025年3月24日最近更新:
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Time (minutes) taken to achieve blood pressure
研究概览
简要总结
Pregnancy-induced hypertension, also called gestational hypertension, is high blood pressure that develops after 20 weeks of pregnancy and resolves after childbirth. Labetalol works by blocking both alpha-1 and beta-adrenergic receptors, which leads to reduced vascular resistance and heart rate, thereby lowering blood pressure. Nifedipine works by relaxing blood vessels, which reduces vascular resistance and lowers blood pressure. In this study we try to understand the efficacy of both the drugs.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 19.00 Year(s) 至 45.00 Year(s)（—）
- 性别
- Female
入选标准
- •Pregnant women more than 20 weeks of gestation with blood pressure reading ≥140/90 mmHg and medical decision to control blood pressure rapidly were included for the study.
排除标准
- •Patients who do not consent for participation in the study
- •Patients with chronic hypertension i.e. known cases of hypertension or hypertension diagnosed first time in pregnancy but before 20 weeks of gestational age.
- •Women with a history of heart rhythm abnormality, heart failure, asthma, allergy to either of the drugs, non-pregnancy related hypertension are to be excluded from the study.
- •Patients receiving any other antihypertensive drug preceding 72 hours of admission will also be excluded from study.
- •History of Smoking
- •Any chronic medical illness with pre existing renal disease, liver disease
- •Patients who are not willing to give consent.
结局指标
主要结局
Time (minutes) taken to achieve blood pressure
时间窗: 8 weeks
≤140/90 mmHg
时间窗: 8 weeks
Total antihypertensive doses to achieve blood pressure
时间窗: 8 weeks
次要结局
- Mode of delivery(Baby weight)
研究者
Swagata Dey
Tezpur Medical College and hospital
研究点 (1)
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