JPRN-UMIN000040836招募中未知
Elucidation of tumor immuno-regulatory mechanism via androgen receptor signal in breast cancer - Elucidation of tumor immuno-regulatory mechanism via androgen receptor signal in breast cancer
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 入组人数
- 45
研究概览
简要总结
For 45 breast cancer clinical specimens, the number of tumor infiltrating leukocytes and the ratio of various immune cell fractions to them are measured by multicolor flow cytometry. AR and ZAG expression was quantified by immunostaining. AR expression showed a positive correlation with the proportions of NK cells and NKT cells, and ZAG expression showed an inverse correlation with the proportions with Monocytes (including Macrophage-like cells) and MDSC.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20years-old 至 ot applicable（—）
- 性别
- Female
入选标准
- 未提供
排除标准
- •1) Age less than 20 years old. 2) Anyone or more of steroids, immunosuppressants, sex hormones, and endocrine therapeutics have been administered within the past 3 months. 3) Pathological conditions (primary immunodeficiency, HIV infection, hematological cancer (including past history)) that may be accompanied by abnormal systemic immune function. 4) Breast cancer diagnosed by incision biopsy. 5) Those with clear hematoma formation or infection after needle biopsy. 6) Those who received pre-operative drug therapy. 7) In case of insufficient tumor sample for routine pathological examination if sample are collectied for this study.
研究者
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