Prediction of Outcome After Acute Stroke: Validation of CT-DRAGON Versus a Simplified CT-DRAGON Score
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 700
- 试验地点
- 1
- 主要终点
- Modified Rankin Scale at day 90
研究概览
简要总结
The CT-DRAGON score can predict long-term functional outcome after acute stroke treated by thrombolysis. However, implementation in clinical practice is hampered by a lack of validation in the broad spectrum of stroke patients undergoing thrombectomy, whether or not in combination with thrombolysis or conservative treatment. Furthermore, the CT-DRAGON score considers multiple items, which are not always readily available in every setting. This study aims to investigate whether either a simplified version of the CT-DRAGON score with only three clinical items or a machine learning technique could be as powerful and more feasible.
详细描述
The investigators aim to validate the CT-DRAGON score in all ischaemic stroke localisations and for all treatment options, including a conservative treatment policy. The predictability will then be compared with on the one hand simplified prognostic models that include only a selective set of highly predictive parameters that have already been described in the literature, such as patient age, National Institutes of Health Stroke Scale (NIHSS) and pre-stroke modified Rankin Scale (mRS). On the other hand, machine learning techniques, that incorporate a large set of variables and have recently shown some promising results, will also be applied to predict long-term outcome after ischaemic stroke.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •all patients diagnosed with a stroke
排除标准
- 未提供
结局指标
主要结局
Modified Rankin Scale at day 90
时间窗: 90 days after the onset of stroke
The modified rankin scale will be assessed at 90 days at a consultation or by a telephonic interview which is standard of care in the hospital. The scale runs from 0-6, running from perfect health without symptoms to death.
Modified Rankin Scale at 7 days after discharge
时间窗: 7 days after discharge at the hospital
The modified rankin scale will be assessed at 7 days after discharge by a telephonic interview which is standard of care in the hospital. he scale runs from 0-6, running from perfect health without symptoms to death.
次要结局
- Analysis of the hospitalization cost after the onset of stroke(90 days after the onset of stroke)
- PROMIS 10 questionnaire at 90 days after the onset of stroke(90 days after the onset of stroke)
- PROMIS 10 questionnaire at 7 days after discharge(7 days after discharge)
- NIHSS at 90 days after the onset of stroke(90 days after the onset of stroke)
研究者
Dieter Mesotten
Principal Investigator
Ziekenhuis Oost-Limburg