From Single Child to Family Planning: Determinants of Returning to ART to Build the Desired Family in a Monocentric Italian Cohort.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 5,852
- 主要终点
- Return rate of couples who had achieved a first pregnancy and returned to pursue a second child.
研究概览
简要总结
This monocentric retrospective cohort study aims to investigate reproductive behavior and subsequent family-building outcomes in couples who achieved a first live birth through assisted reproductive technology (ART) at a university-affiliated fertility center in Italy. All couples obtaining a first live birth between January 2010 and December 2020 will be included and followed until December 2024. The primary objective is to evaluate the rate of return for further ART treatment after the first live birth. Secondary objectives include assessing cumulative live birth rate (CLBR) for the second and third live birth. Associations between return behavior and clinical factors, including maternal age, presence of cryopreserved oocytes or embryos, and treatment characteristics, will be analyzed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 43 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Copules underwent ART treatment at the Humanitas Fertility Center (Rozzano, Milan)
- •Copules achieved a first clinical pregnancy resulting from ART between January 2010 and December 2020
- •heterosexual couples in which the maternal age was between 18 and 43 years old
排除标准
- •Couples who did not meet the inclusion criteria
- •ART cycles involving preimplantation genetic testing for aneuploidy (PGT-A)
- •Use of donor gametes (oocyte or sperm donation)
研究组 & 干预措施
Returners
Couples who achieved a first live birth through ART at the study center and subsequently returned to undergo one or more additional ART cycles for further reproductive attempts during follow-up.
Non-returners
Couples who achieved a first live birth through ART at the study center and did not return for further ART treatment after the index birth during the follow-up period.
结局指标
主要结局
Return rate of couples who had achieved a first pregnancy and returned to pursue a second child.
时间窗: From January 2010 to December 2024
Analysis of the return rate of couples who had already achieved a first pregnancy and pursued a second child, with a comprehensive evaluation of the clinical, demographic, and treatment-related factors that may influence their likelihood of returning for additional ART attempts. This analysis aims to identify which characteristics are associated with a higher or lower probability of continuing their family-building journey after the initial live birth.
次要结局
- Cumulative live birth rate of couples who had already achieved a first live birth and attempted to conceive a second child(From January 2010 to December 2024)
研究者
Michele Tedeschi
Dottor
Istituto Clinico Humanitas